Interestingly, in a study of drug nave first episode manic patients ( n = 56), serum ferritin was positively correlated with the BPRS (Brief Psychiatric Rating Scale) and YMRS (Young Mania Rating Scale) scores and patients showed higher inflammatory indices compared to their matched controls [127]
The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48
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